VKORC1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comVKORC1 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > VKORC1(Gene name) > Human

VKORC1 (Gene name),

Vitamin K epoxide reductase complex subunit 1 (Protein name ), VKOR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

VKORC1(MSTP134;MSTP576;UNQ308/PRO351;VKOR);

Protein name:

Vitamin K epoxide reductase complex subunit 1;

Alternative:

Vitamin K1 2,3-epoxide reductase subunit 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

163

Sequence:

50:

100:

150:

163:

RKVQEPQGKA | KRH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:79001

Pfam:

PF07884

String:

Q9BQB6

UniGene:

Hs.324844

MIM:

122700

STRING:

9606.ENSP00000378426

Uniprot:

Q9BQB6

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ELISA Kit for Human Vitamin K epoxide reductase complex subunit 1

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E0505m

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96T

ELISA Kit for Human Vitamin K epoxide reductase complex subunit 1

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E0505r

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96T

ELISA Kit for Human Vitamin K epoxide reductase complex subunit 1

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E0505b

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96T

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ELISA Kit for Human Vitamin K epoxide reductase complex subunit 1

Cat.:

E0505h

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96T

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CLIA Kit for Human Vitamin K epoxide reductase complex subunit 1

Cat.:

U0505h

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96T

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CLIA Kit for Human Vitamin K epoxide reductase complex subunit 1

Cat.:

U0505m

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96T

CLIA Kit for Human Vitamin K epoxide reductase complex subunit 1

Cat.:

U0505r

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96T

CLIA Kit for Human Vitamin K epoxide reductase complex subunit 1

Cat.:

U0505b

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96T

Polyclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1

Cat.:

P0505Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1

Cat.:

P0505Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1

Cat.:

P0505Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1

Protein for Human Vitamin K epoxide reductase complex subunit 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2."
Rost S. , Fregin A. , Ivaskevicius V. , Conzelmann E. , Hoertnagel K. , Pelz H.-J. , Lappegard K. , Seifried E. , Scharrer I. , Tuddenham E.G.D. , Mueller C.R. , Strom T.M. , Oldenburg J.
Nature427:537-541(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANTS CMRES LEU-29; ALA-45; GLY-58 AND ARG-128;VARIANT VKCFD2 TRP-98
tissue: Kidney.
2.

"Identification of the gene for vitamin K epoxide reductase."
Li T. , Chang C.-Y. , Jin D.-Y. , Lin P.-J. , Khvorova A. , Stafford D.W.
Nature427:541-544(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
3.

Liu B. , Qin B.M. , Sheng H. , Zhao B. , Liu Y.Q. , Wang X.Y. , Zhang Q. , Song L. , Lu H. , Xu H.S. , Zheng W.Y. , Gong J. , Wang Y.B. , Liu Y.Q. , Zhang C.N. , Shi Y. , Wang W. , Zhang Z. , more...
Submitted (2003-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Aorta.
4.

SeattleSNPs variation discovery resource
Submitted (2004-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue: Brain.
6.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
9.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-163 (ISOFORM 1)
10.

"Vitamin K epoxide reductase: homology, active site and catalytic mechanism."
Goodstadt L. , Ponting C.P.
Trends Biochem. Sci.29:289-292(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POTENTIAL REDOX-ACTIVE SITE
11.

"The genetic basis of resistance to anticoagulants in rodents."
Pelz H.J. , Rost S. , Hunerberg M. , Fregin A. , Heiberg A.C. , Baert K. , MacNicoll A.D. , Prescott C.V. , Walker A.S. , Oldenburg J. , Muller C.R.
Genetics170:1839-1847(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ARG-35; SER-56; LEU-120; LEU-128 AND TYR-139;CATALYTIC ACTIVITY;ENZYME REGULATION;FUNCTION
12.

"Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation."
Tie J.-K. , Nicchitta C. , von Heijne G. , Stafford D.W.
J. Biol. Chem.280:16410-16416(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY;SUBCELLULAR LOCATION
13.

"Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin."
Rost S. , Fregin A. , Hunerberg M. , Bevans C.G. , Muller C.R. , Oldenburg J.
Thromb. Haemost.94:780-786(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;POTENTIAL REDOX-ACTIVE SITE;CATALYTIC ACTIVITY;ENZYME REGULATION;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-16; CYS-43; CYS-51; SER-57; CYS-85; CYS-96; ARG-98; CYS-132; CYS-135 AND TYR-139;CHARACTERIZATION OF VARIANT VKCFD2 TRP-98
14.

"Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners."
Schulman S. , Wang B. , Li W. , Rapoport T.A.
Proc. Natl. Acad. Sci. U.S.A.107:15027-15032(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY
15.

"Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation."
Rishavy M.A. , Usubalieva A. , Hallgren K.W. , Berkner K.L.
J. Biol. Chem.286:7267-7278(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION;SUBCELLULAR LOCATION;TOPOLOGY;MUTAGENESIS OF CYS-43 AND CYS-51
16.

"Human vitamin K epoxide reductase and its bacterial homologue have different membrane topologies and reaction mechanisms."
Tie J.K. , Jin D.Y. , Stafford D.W.
J. Biol. Chem.287:33945-33955(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY;CATALYTIC ACTIVITY;ENZYME REGULATION;FUNCTION
17.

"Membrane topology for human vitamin K epoxide reductase."
Wu S. , Tie J.K. , Stafford D.W. , Pedersen L.G.
J. Thromb. Haemost.12:112-114(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
18.

"Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment."
Watzka M. , Geisen C. , Bevans C.G. , Sittinger K. , Spohn G. , Rost S. , Seifried E. , Muller C.R. , Oldenburg J.
J. Thromb. Haemost.9:109-118(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMRES THR-26; LEU-29; GLY-36; TYR-36; TRP-52; PHE-56; LEU-59; CYS-59; GLY-66; MET-66; ALA-71; SER-77; TYR-77; ASN-123 AND HIS-139

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